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Role of lubricin and boundary lubrication in the

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Molecular synergy in biolubrication: The role of cartilage oligomeric matrix protein (COMP) in surface-structuring of lubricin - ScienceDire

Molecular synergy in biolubrication: The role of cartilage oligomeric matrix protein (COMP) in surface-structuring of lubricin ... B.C. Fleming, M.L. Warman, G.D. JayRole of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Proc. Natl ...

NAVER Academic > Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosi

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis. Author Kimberly A Waller, Ling X Zhang, Khaled A Elsaid, Braden C Fleming, Matthew L Warman, Gregory D Jay Publisher ...

Transcription, Translation, and Function of Lubricin, a Boundary Lubricant, at the Ocular Surface | Cornea | JAMA Ophthalmology | JAMA Netwo

Lubricin plays a critical role as a boundary lubricant in articulating joints. 1-4 This amphiphilic ... responsible for boundary mode lubrication at the ocular surface supports the hypothesis of Ehlers, 28 who theorized that boundary lubrication must take place 29 28 ...

Prevention of cartilage degeneration and gait asymmetry by lubricin tribosupplementation in the rat following anterior cruciate ligament .

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Proteoglycan 4 - Wikiped

Function Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an important role in joint lubrication and synovial homeostasis. When first isolated, cartilage lubricin was called "superficial zone protein" (SZP).

Full-Length Recombinant Human Proteoglycan 4 Interacts with Hyaluronan to Provide Cartilage Boundary Lubrication | SpringerLi

Full-Length Recombinant Human Proteoglycan 4 Interacts with Hyaluronan to Provide Cartilage Boundary Lubrication Authors Authors and affiliations ...

Proteoglycan 4 - Wikiped

Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an important role in joint lubrication and synovial homeostasis. When first isolated, cartilage lubricin was called "superficial zone protein" (SZP). Lubricin ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apo

Title: Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Authors: Waller, K. A.; Zhang, L. X.; Elsaid, K. A.; Fleming, B. C.; Warman, M. L.; Jay, G. D. Publication: Proceedings of the National Academy of Sciences, vol. 110, issue ...

The biology of Lubricin: Near frictionless joint motion - ScienceDire

Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an important role in cartilage integrity. In healthy joints, lubricin molecules coat the cartilage surface, providing boundary lubrication and preventing cell and protein adhesion.

The role of lubricin in the mechanical behavior of synovial fluid. | Sigma-Aldri

Abstract Synovial fluid is a semidilute hyaluronate (HA) polymer solution, the rheology of which depends on HA-protein interactions, and lubricin is a HA-binding protein found in synovial fluid and at cartilage surfaces, where it contributes to boundary lubrication under ...

Lubricin: New Promise for Joint-Preserving Therapy | Rheumatology Netwo

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis. Proc Natl Acad Sci (2013) 110:5852-5857 23. Waller KA, Zhang LX, Fleming BC, Jay GD. Preventing friction-induced chondrocyte apoptosis: comparison of human synovial fluid ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos

These results demonstrate a direct connection between lubricin, boundary lubrication, and cell survival and suggest that supplementation of synovial fluid with lubricin may be an effective treatment to prevent cartilage deterioration in patients ...

The role of lubricin in the mechanical behavior of synovial fluid | G D Jay | Request P

Synovial fluid is a semidilute hyaluronate (HA) polymer solution, the rheology of which depends on HA–protein interactions, and lubricin is a HA-binding protein found in synovial fluid and at cartilage surfaces, where it contributes to boundary lubrication under load.

The role of lubricin in normal and pathological joint tissue: A contemporary review.OA Anato

The role of lubricin in normal and pathological joint tissue: a contemporary review G Musumeci 1* Authors affiliations (1) ... It has been shown that lubricin is critical to normal joint function, providing boundary lubrication of congruent articular surfaces under ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos

These results demonstrate a direct connection between lubricin, boundary lubrication, and cell survival and suggest that supplementation of synovial fluid with lubricin may be an effective treatment to prevent cartilage deterioration in patients with genetic or ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Kimberly A. Wallera, Ling X. Zhangb, Khaled A. Elsaidc, Braden C. Fleminga,d,e, Matthew L. Warmanf,g, and Gregory D. Jaya,b,h,1 aCenter for Biomedical Engineering and the ...

Friction force microscopy of lubricin and hyaluronic acid between hydrophobic and hydrophilic surfac

Friction force microscopy of lubricin and hyaluronic acid between hydrophobic and hydrophilic surfaces ... a mixture the two to further understand the role of lubricin in boundary lubrication and to examine the hypotheses that lubri-cin and HA, alone or in ...

The role of lubricin in normal and pathological joint tissue: a contemporary revi

boundary lubrication of congruent articular surfaces under conditions of high contact pressure and near-zero sliding speed. ... The role of lubricin in normal and pathological joint tissue: a contemporary review. OA Anatomy 2013 Feb 01;1(1):2. rod and, in solution ...

The role of lubricin in the mechanical behavior of synovial flui

The role of lubricin in the mechanical behavior of synovial fluid. Jay GD(1), Torres JR, Warman ML, ... where it contributes to boundary lubrication under load. Individuals with genetic deficiency of lubricin develop precocious joint failure. The role of lubricin in We ...

The Role Of Lubricin And Galectins In Osteoarthritis And Cartilage Lubricati

The Role Of Lubricin And Galectins In Osteoarthritis And Cartilage Lubrication By Heidi Reesink Abstract ... and galectins-1 and -3 to determine if lubricin and galectins could synergistically enhance articular cartilage boundary lubrication and; 3) evaluate equine ...