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The tumour suppressor protein VHL targets hypoxia

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The von Hippel–Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis, Seminars ...-7 | DeepDy

Recently, work on the mechanism of action of the von Hippel–Lindau tumour suppressor protein (pVHL) ... The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis Maxwell, P.H.; Wiesener, M.S.; Chang, G.-W ...

The VHL Tumor Suppressor: Master Regulator of H

heterodimeric oxygen-sensitive basic helix-loop-helix transcription factors that play central roles in cellular adaptation to ... Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, et al. The tumour suppressor protein VHL targets [] ...

The multifaceted von Hippel–Lindau tumour suppressor protein - ScienceDire

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis Nature, 399 (6733) (1999), pp. 271-275 Google Scholar M. Ivan, et al.HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for ...

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis - UCL Discove

Type: Article Title: The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis Keywords: ERYTHROPOIETIN GENE, FACTOR 1-ALPHA, ALPHA-SUBUNIT, HEME PROTEIN, EXPRESSION ...

The von Hippel–Lindau tumour suppressor: a multi-faceted inhibitor of tumourigenesis: Trends in Molecular Medici

The proteolytic degradation of hypoxia inducible factor (HIF)α by the von Hippel–Lindau (VHL) tumour suppressor protein (pVHL) has emerged as a key cellular mechanism for the control of adaptive gene expression programmes in response to changes in oxygen ...

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysi

Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. ... View This Abstract Online The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen ...

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. | Sigma-Aldri

Sigma-Aldrich offers abstracts and full-text articles by [P H Maxwell, M S Wiesener, G W Chang, S C Clifford, E C Vaux, M E Cockman, C C Wykoff, C W Pugh, E R Maher, P J ...

Mutation of von Hippel–Lindau Tumour Suppressor and Human Cardiopulmonary Physiolo

The von Hippel–Lindau tumour suppressor protein–hypoxia-inducible factor (VHL–HIF) pathway has attracted widespread medical interest as a transcriptional system controlling cellular responses to hypoxia, yet insights into its role in systemic human ...

The VHL Tumor Suppressor: Master Regulator of H

heterodimeric oxygen-sensitive basic helix-loop-helix transcription factors that play central roles in cellular adaptation to ... Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, et al. The tumour suppressor protein VHL targets [] ...

Von Hippel–Lindau tumor suppressor - Wikiped

The main action of the VHL protein is thought to be its E3 ubiquitin ligase activity that results in specific target proteins being 'marked' for degradation. The most researched of these targets is hypoxia inducible factor 1a (HIF1a), a transcription factor that induces ...

The von Hippel–Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis - ScienceDire

The von Hippel–Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis ... Recently, work on the mechanism of action of the von Hippel–Lindau tumour suppressor protein (pVHL) and studies on hypoxic gene regulation ...

Hypoxia-inducible factors - Wikiped

protein HIF-1α HIF1A hypoxia-inducible factor 1, alpha subunit HIF-1β ARNT aryl hydrocarbon receptor nuclear translocator HIF-2α EPAS1 endothelial PAS domain protein 1 ...

(PDF) Maxwell PH, Wiesener MS, Chang G-W, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, and Ratcliffe PJ. The tumour suppressor .

Maxwell PH, Wiesener MS, Chang G-W, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, and Ratcliffe PJ. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399: 271-275 ...

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis | Natu

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Erythropoietin, tumours and the von Hippel–Lindau gene: towards identification of mechanisms and dysfunction of ...- Oxford Academ

The tumour suppressor protein VHL targets hypoxia‐inducible factors for oxygen‐dependent proteolysis. Nature 1999; 399: 271 –275 Google Scholar 20 Jaakkola P, Mole DR, Tian YM et al. Targeting of HIF‐alpha to the von Hippel–Lindau ubiquitylation complex 2 ...

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysi

Protein knowledgebase UniParc Sequence archive Help Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. UniRef Sequence clusters Proteomes Protein sets from fully sequenced genomes Annotation systems ...

VHL — Википеди

, HRCA1, RCA1, VHL1, pvon Hippel-Lindau tumor suppressor Внешние IDs Генная онтология Функции ... Некоторые мутации в гене VHL Мутация OMIM Тип мутации Тип болезни (комментарии) Leu63Pro 608537.0016 VHL Arg64Pro 608537.0015 VHL ...

Understanding the VHL Tumor Suppressor Complex | The Scientist Magazine

... M.E. Cockman, C.C. Wykoff, C.W. Pugh, E.R. Maher, P.J. Ratcliffe, "The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis", Nature, 399:271-5, May 20, 1999. (Cited in 156 ...

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis - Houston Methodi

Hypoxia-inducible factor-1 (HIF-1) has a key role in cellular responses to hypoxia, including the regulation of genes involved in energy metabolism, angiogenesis and apoptosis. The α subunits of HIF are rapidly degraded by the proteasome under normal conditions ...